Cannabichromene is a phytocannabinoid that comes from cannabis. It’s non-psychoactive and has many health benefits. It blocks inflammation and pain and inhibits apoptosis in cells. It is the most abundant cannabinoid in plants.
Cannabichromene is a phytocannabinoid
Cannabichromene is an essential component of cannabis and has several beneficial effects. It has an entourage effect that works with other cannabinoids, such as CBD and THC. It is believed that cannabichromene may have broad implications for human health, ranging from improving cognitive function to combating cancer. To fully understand the consequences of this substance, additional study is needed.
Unlike other cannabinoids, cannabichromene is relatively unknown to the public. However, the compound was discovered more than 50 years ago, and its use in medical research is now gaining wider acceptance. According to a study, it may offer several health advantages, including the capacity to lower inflammation, improve mood, and fight cancer.
Non-psychoactive cannabinoid
A cannabinoid called cannabichromene is a trace quantity in hemp and cannabis plants. Anti-inflammatory, antimicrobial, and pain-relieving qualities are thought to exist in it. Neuroprotection has also been connected to it. It may also have a role in treating inflammatory skin conditions, including acne. It inhibits inflammatory proteins and the production of fatty acids in the sebaceous gland.
Cannabichromene was first discovered in 1966 and is the third most abundant cannabinoid in cannabis after THC and CBD. However, it makes up less than one percent of the mass of the cannabis plant. It is not present in hemp flowers in their natural form but can be found in cbc oil produced by a few vendors. They contain ten to fifty mg of cannabichromene per serving.
Blocks pain and inflammation
A rising number of US states have approved the use of marijuana for medical conditions such as paralysis, chemotherapy-induced nausea, cancer-related pain, and spasticity. The use of marijuana has also been linked to improved quality of life for patients. Cannabinoids are also used in the treatment of anxiety disorders.
Cannabichromene is one of the most abundant phytocannabinoids. It also potentiates some of the products of D9-THC in vivo. However, nothing is known regarding its precise function in interacting with cannabinoid receptors. In one study, the compound was administered to cell-cultured atT20 cells, stably expressing human CB1 and CB2 receptors. It also appeared to potentiate some of the effects of D9-THW in this system.
It blocks apoptosis
Cannabinoids, specifically cannabichromene, have been found to block apoptosis in cancer cells. These compounds are also antineoplastic, inhibiting the growth of cancer cells. They also inhibit the proliferation of cancer cells by arresting them at the G0/G1 phase.
These compounds are also potential therapeutic targets for melanoma. In one study, researchers found that cannabichromene inhibited apoptosis in gastric cancer cells, a type of cancer that expresses a high frequency of CB2 receptors. Another study published in J Cell Biochem showed that the cannabichromene compound ACPA inhibited the growth of non-small cell lung cancer cells, inhibiting the Akt/PI3K and JNK pathways.
Other substances in Cannabis sativa L. have also been studied for their anticancer effects. For example, the sesquiterpene b-caryophyllene inhibited apoptosis in human cells by inhibiting the activation of TRPV1 receptors. In addition, b-caryophyllene enhanced the antiproliferative and proapoptotic effects of classical chemotherapeutic agents.
Blocks TRP cation channels
TRP cation channels are membrane proteins found chiefly in animal tissues. They regulate many cellular functions, including transcription, translation, and migration. They are sensitive to electrical signals and chemicals. They contribute to several cardiovascular diseases.
TRP cation channels transmit calcium and sodium from neurons to other cell types. In mammals, these channels are located on sensory neurons. Initially, these channels were known to be involved in nociception. They are sensitive to plant secondary metabolites or compounds that mimic pain and burning sensations. Cannabinoids act on these channels, including THC, CBD, and CBN.
